![]() ![]() ![]() Subjects AA showed a reduction in lipoperoxidation and DNA damage, but in these subjects, there was upregulation of thiols and GPX levels at enzymatic and mRNA expression levels. ![]() The results showed differential antioxidant responses according to genotypes. We performed an analysis of the acute antioxidant effect of one-time ingestion of 10 g of BN among healthy adult subjects carrying different SOD2 genotypes. Because there evidence suggesting that habitual consumption of fruits and vegetables can minimize this risk, we hypothesized that BN is beneficial to subjects with genotype AA by decreasing the basal SA-HP imbalance. The AA genotype results in higher SOD2 levels leading to an increase in hydrogen peroxide levels related to a risk of some cancers. This effect could be relevant to human health among people with a genetic superoxide anion-hydrogen peroxide (SA-HP) imbalance caused by a single nucleotide polymorphism located in the gene of manganese-dependent superoxide dismutase (Val16Ala-SOD2, rs4880). Some plants are rich in a specific antioxidant that has a glutathione peroxidase -like effect, such as Brazil nut (BN) ( Bertholletia excelsa), rich in selenium. The antioxidant effect of Brazil nut ( Bertholletia excelsa ) is influenced by a genetic superoxide-hydrogen peroxide imbalance in healthy humans. 97105-900, Santa Maria-RS, BrazilĬitation: Cruz IBM, Motta JR, Lenz AF, et al. Please type the correct Captcha word to see email ID.ġMorphology Department, Federal University of Santa Maria, BrazilĢGraduate Program in Gerontology, Federal University of Santa Maria, BrazilģGraduate program of Pharmacology, Federal University of Santa Maria, BrazilĤGraduate Program in Pathology, Federal University of Health Sciences of Porto Alegre, BrazilĦOpen University of the Third Age, State University of Amazonas, BrazilĬorrespondence: Fernanda Barbisan, Graduate Program in Gerontology, Federal University of Santa Maria, Centro de Educação Física e Desportos, Avenida Roraima, 1000 prédio 51, sala 2032. Regret for the inconvenience: we are taking measures to prevent fraudulent form submissions by extractors and page crawlers. ![]()
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